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Fly into Frankfurt in June or July for the warmest, driest weather and bright sunny days that stretch on for 16 hours or so in mid summer. There's a plethora of outdoor events to get involved in too, from al fresco pub sessions in the beer gardens to beach bars on the River Main. December is another popular time to visit as the city hosts one of Germany’s largest Christmas markets.
To beat the crowds (and the peak prices of mid summer), fly to Frankfurt between April and June or September and October. Rainfall is low during these months, the weather is nice and mild and the city's gardens are blooming. When you're not out exploring the city, get involved in the Ratsweg Fairground folk festival and the Frankfurter Sausage Festival.